Sydney veterinary science researchers study crocodile immune system

The immune systems of crocodiles and alligators have remained relatively unchanged for centuries despite their worldwide distribution, as revealed for the first time by University of Sydney researchers. This new knowledge could assist in the conservation and breeding strategy of Australian freshwater and saltwater crocodiles.

Dr Jaime Gongora, research project leader from the University of Sydney’s Faculty of Veterinary Science said, “Alligators and crocodiles occupy an evolutionary mid-point between mammals and birds so they provide a unique link. Our research helps address fundamental questions about how evolution drives and maintains genetic diversity of the immune genes.
“The study looked at the diversity and evolutionary mechanisms of two primary gene classes of the major histocompatibility complex (MHC), key components of the immune system. The study investigated twenty species of crocodilians including the two Australian crocodile species; freshwater and saltwater crocodiles.
“This research helps to close a gap in our knowledge of immune gene evolution particularly since the crocodilian families (crocodiles and alligators) diverged from a common ancestor ninety million years ago.”
The MHC is a group of genes that help the immune system identify microbes and parasites. They play an important role in disease resistance, as diverse genes allow animals to resist a wider range of diseases. The research published recently in the journals PLOS ONE and Immunogenetics shows that some of the genes involved in the fight against viruses, bacteria and parasites have remained the same across all crocodilian species while other immune genes seem to have diversified in crocodiles.
“The diverse environments occupied by many crocodilians, whether saltwater crocs in the Northern Territory or alligators in Florida, appear to have exposed crocodilians immune genes to a wide range of germs,” Dr Gongora said.
Researchers found multiple instances of crocodilians losing and/or duplicating genes showing that their immune system is still responsive to evolutionary changes.
“We now have a genetic resource to understand the immune system in crocodilians, thanks to this research. It will enable genetic investigations of how these animals respond to local conditions including susceptibility to disease,” said lead author of the article Weerachai Jaratlerdsiri, who recently completed his PhD at the University of Sydney.
“In an agricultural context, crocodiles are produced for their skins as part of a very successful sustainable-use conservation strategy. Part of this strategy is to place an economic value on the wild population, in this case the crocodile eggs, which are collected and artificially incubated before rearing the offspring in captivity. However, since these animals are not domesticated, no selection against bugs has occurred. Thus, understanding the genetic regulation of disease susceptibility will provide crocodile producers with selection tools and lessen the reliance on vaccinations and antibiotics,” said Dr Sally Isberg, honorary associate at the University of Sydney and Managing Director of the Centre for Crocodile Research which consults to the Australian crocodile industry.
“The innovative and fundamental knowledge generated from this research serves as the base for further research into the immunological fitness of wild and farmed populations, especially to explain how they maintain the health of their immune system to deal with parasites and microbes.”
The researchers suggest that throughout crocodilian evolution, immune gene diversity responded to disease-causing organisms in the environment. This might provide further insights into disease resistance by explaining how immune genes evolve in other vertebrates, in particular reptiles.
University of Sydney colleagues including Dr Damien Higgins, Dr Lee Miles and Dr Simon Ho contributed to these studies.

Proposed Doctor of Veterinary Medicine at Sydney Veterinary School

The University of Sydney has offered a five-year, Bachelor of Veterinary Science in past years. The university is now transitioning its vet program from a Bachelor of Veterinary Science to a Doctor of Veterinary Medicine program. In 2013, the Sydney Veterinary School offered its last Bachelor of Veterinary Science intake. In 2015, it is planned that the faculty will offer a four-year, graduate-entry Doctor of Veterinary Medicine degree.
OzTREKK will post information regarding the new DVM program as soon as it is received from the University of Sydney Veterinary School.
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Do you have questions about Sydney Veterinary School and about studying veterinary programs at Australian universities? Contact OzTREKK’s Australian Veterinary Schools Officer Rachel Brady by emailing rachel@oztrekk.com or by calling 1 866-698-7355 (toll free in Canada).